TOXICOLOGY OF ARTIFICIAL NANOMATERIALS (ENMS)
Many of the toxicological models and methods used to investigate the health risks of nanomaterials have their origin in particle and fiber toxicology studies.
ARE ENM HARMFUL AND, IF SO, WHAT MECHANISMS AND PROPERTIES EXPLAIN ITS ![]()
TOXICITY?
The main toxicological studies have focused on the effects on the respiratory tract, associated with the exposure of aerosols; nanoparticles have been observed to reach the interstitium and blood, which may represent a pathway for the translocation of inhaled nanoparticles from the lung to secondary organs.
TOXICITY?
The main toxicological studies have focused on the effects on the respiratory tract, associated with the exposure of aerosols; nanoparticles have been observed to reach the interstitium and blood, which may represent a pathway for the translocation of inhaled nanoparticles from the lung to secondary organs.
Researchers such as Maynard and Kuempel (2005) indicate that the toxicity of naoparticles is not related to the physicochemical properties that make up a material, but rather to the confluence of multiple mechanisms.
On the other hand, (Oberdörster et al. 1992) demonstrated that insoluble nanoparticles have an inhalation toxicity proportional to the total surface area (and, therefore, inversely proportional to the individual particle size)
By 2010, knowledge in toxicology increased considerably and knowledge was focusing on the integration of other fields related to occupational health (Savolainen et al. 2010a).
Temas relacionados:
toxicological models
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